Ryanodine receptor and junctional membrane structure.
نویسندگان
چکیده
منابع مشابه
Ryanodine receptor structure: progress and challenges.
Ryanodine Receptors as Regulated Guardians of Intracellular Ca Stores Ryanodine-sensitive Ca2 release channels, also known as the ryanodine receptors (RyRs),2 are homotetramers of an 550-kDa subunit (Fig. 1) that are resident proteins of intracellular membranes such as the sarcoplasmic/endoplasmic reticulum. RyRs are responsible for the regulated release of Ca2 from these lumenal stores. Over t...
متن کاملComplex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane.
Several key proteins have been localized to junctional sarcoplasmic reticulum which are important for Ca2+ release. These include the ryanodine receptor, triadin, and calsequestrin, which may associate into a stable complex at the junctional membrane. We recently purified and cloned a fourth component of this complex, junctin, which exhibits homology with triadin and is the major 125I-calseques...
متن کاملDisrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
BACKGROUND Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ release channels on sarcoplasmic reticulum within junctional membrane complexes. Although previous studies revealed a loss of junctional membrane complexes and embryonic lethality in germ-line junctophilin-2 (JPH2) knockout mice, it has remained un...
متن کاملHeart Failure Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice
Background—Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca 2ϩ channels and Ca 2ϩ release channels on sarcoplasmic reticulum within junctional membrane complexes. Although previous studies revealed a loss of junctional membrane complexes and embryonic lethality in germ-line junctophilin-2 (JPH2) knockout mice, it has remained ...
متن کاملStructure and function of Ca-ATPase and the ryanodine receptor
Contraction of striated muscle results from a rise in cytoplasmic calcium concentration in a process termed excitation/contraction coupling. Most of this calcium moves back and forth across the sarcoplasmic-reticulum membrane in cycles of contraction and relaxation. The channel responsible for release from the sarcoplasmic reticulum is the ryanodine receptor, whereas Ca-ATPase effects reuptake ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2003
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.121.203